Energy & Focus
Fight fatigue and stay sharp through the day.
Fatigue usually traces back to the basics — sleep, stress, and nutrition — before it's ever a supplement problem. These options support the body's normal energy production and can help most when a genuine nutrient gap or a high-demand stretch is part of the picture.
What to look for
B vitamins, CoQ10, and adaptogens that support natural energy production.
What the research supports
Recommended supplements
- B-ComplexB vitamins are cofactors your cells use to turn food into usable energy. Supplementing mainly helps when intake is low, which is common with vegetarian or vegan diets, heavy alcohol use, or certain medications.
- CoQ10A compound your mitochondria use to generate energy; levels decline with age and with statin use. A meta-analysis of randomized trials found it can modestly reduce fatigue.
- RhodiolaAn adaptogenic herb traditionally used for stamina and stress-related tiredness. Early trials are encouraging but had methodological limits, so treat it as promising rather than proven.
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Things to keep in mind
If fatigue is persistent, new, or severe, see your provider first — it can signal thyroid, iron, sleep, or mood issues that a supplement won't fix. Rhodiola and high-dose B vitamins can interact with some medications.
Educational information only. These statements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement.
References
Recommendations on this page are informed by published research. This is educational information, not medical advice.
- Ishaque S, Shamseer L, Bukutu C, Vohra S. Rhodiola rosea for physical and mental fatigue: a systematic review. BMC Complement Altern Med. 2012;12:70. View study →Note: Early trials are promising but had methodological limitations, so the evidence isn't yet definitive.
- Tsai IC, Hsu CW, Chang CH, et al. Effectiveness of Coenzyme Q10 Supplementation for Reducing Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Front Pharmacol. 2022;13:883251. View study →